منابع مشابه
Intranasal Corticosteroid Safety
The safety and effi cacy of intranasal corticosteroids (INCs) are well established for the management of allergic rhinitis, rhinosinusitis, and nasal polyps. As seen in numerous studies, INCs demonstrate markedly reduced systemic bioavailability compared with oral and even inhaled corticosteroids and have shown an excellent safety profi le over 3 decades of use. Nonetheless, concerns remain amo...
متن کاملCongenital Intranasal Glioma
Congenital midline swellings of nose are encountered rarely, and nasal gliomas constitute about 5% of such lesions. Various theories have been suggested to explain the pathogenesis. Imaging preferably by MRI is mandated to study the extent and to rule out intracranial extension. Treatment is complete excision, and the approach depends upon the extent of the lesion and availability of expertise....
متن کاملIntranasal administration of drugs.
OBJECTIVE To investigate how nasally applied substances distribute in the nose depending on the form of application. DESIGN Observer-blinded study. SETTING University hospital research unit. PARTICIPANTS Fifteen healthy volunteers aged 22 to 32 years. INTERVENTIONS Forms of application included (1) nasal drops applied with a pipette, (2) nasal spray, and (3) a system producing squirts. ...
متن کاملIntranasal Midazolam for Seizures
Seizures in children are a frightening experience for families and care providers. Because the duration of seizure activity impacts on morbidity and mortality, effective methods for seizure control should be instituted as soon as possible, preferably before arrival at the hospital. Since parental methods of drug delivery are not available to most caregivers, and rectal diazepam, the most common...
متن کاملIntranasal delivery of morphine.
Morphine administered nasally to humans as a simple solution is only absorbed to a limited degree, with a bioavailability of the order of 10% compared with intravenous administration. This article describes the development of novel nasal morphine formulations based on chitosan, which, in the sheep model, provide a highly increased absorption with a 5- to 6-fold increase in bioavailability over ...
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ژورنال
عنوان ژورنال: Practica Oto-Rhino-Laryngologica
سال: 1999
ISSN: 1884-4545,0032-6313
DOI: 10.5631/jibirin.92.861